If you’ve ever felt like you’re “doing everything right” — eating the same, exercising the same — yet still gaining weight… then read on.
I recently sat down with obesity medicine specialist Dr. Spencer Nadolsky for a deep, honest, and eye-opening conversation about weight loss, GLP-1 medications (like Ozempic, Wegovy, and Zepbound), and why biology — not just willpower — plays a much bigger role than most of us have been led to believe.
One of the most important opinions Dr. Nadolsky shares is this: most of us dramatically underestimate how much we eat and overestimate how much we move. Even doctors and dietitians can be off by 30–50%. Add in ultra-processed foods that are literally engineered by food scientists to be hyper-palatable and hard to stop eating, and it becomes clear — this isn’t a personal failure. It’s a biological and environmental setup.
One question I asked him is why so many women notice weight gain in their 30s, 40s, and beyond — even when nothing “seems” to have changed. His belief is that disrupted sleep, increased stress, perimenopause, and subtle shifts in eating patterns can all quietly push calorie intake up without you realizing it. When you’re tired, stressed, or hormonally disrupted, your brain is biologically driven to crave quick, easy energy — usually in the form of sugar and refined carbs.
What Is “Food Noise” — and Why Silencing It Can Be Life-Changing
One of the most powerful concepts we discussed is something many people feel but have never had a name for: food noise.
Food noise is that constant background chatter in your brain about food.
– What you’re going to eat next.
– What’s in the pantry.
– Leftovers in the fridge.
– Cravings that seem to pop up out of nowhere — even when you’re not physically hungry.
For some people, food noise is relentless. It can feel like a little voice that never turns off, constantly nudging you toward snacks, treats, or “just one more bite.” Dr. Nadolsky explains that for many patients, this isn’t a character flaw — it’s biology.
GLP-1 medications don’t just reduce appetite. For many people, they quiet this mental obsession with food. Patients often describe it as finally having peace of mind around eating — being able to stop when satisfied, not thinking about food all day, and feeling mentally free for the first time in years.
For some, silencing food noise is more life-changing than the number on the scale. I’ve heard this from many of my patients.
Do you find all of this interesting? On the podcast we get into the real science behind GLP-1 medications, including:
- Who is actually a good candidate — and who probably isn’t
- Why BMI alone is an outdated way to decide treatment
- The truth about muscle loss (and how to protect your muscle)
- Why resistance training and protein matter more than ever
- Whether you really have to stay on these medications forever
- The surprising anti-inflammatory benefits some patients report
- And the controversial idea of “microdosing” GLP-1s
We even discuss why sleep deprivation and chronic stress can literally rewire your brain to crave ultra-processed foods — something many busy parents and perimenopausal women experience firsthand.
If you’ve been confused by the headlines, frustrated with your body, or curious whether GLP-1 medications might be right for you, this episode will give you nuance, clarity, and real medical insight — not hype.
It’s called The Truth About GLP-1 Weight Loss Drugs: Muscle Loss, Microdosing & Long-Term Use.
To listen on Apple devices, click HERE.
To listen on Spotify, click HERE.
To listen on Google/YouTube podcasts, click HERE.
